abstract:OBJECTIVES:The study aims to understand geneome diversification and complexity that developed in Acute myeloid leukemia (AML). METHODS:Next-generation sequencing (NGS) was used to identify the genetic profiles of 22 genes relevant to hematological malignancy in 204 patients with de novo non-M3 AML. RESULTS:At time of i...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2020.1858610
更新日期:2021-12-01 00:00:00
abstract::This study aimed to examine the pharmacological profiles of multiple chemo drug candidates in systematic circulation to enhance their specific interactions with five human cancer cell lines. ZnO nanoparticles were successfully bound with chemo drugs via physical adsorption. The drug loading capacity was confirmed by F...
journal_title:Artificial cells, nanomedicine, and biotechnologypub_type: 杂志文章
doi:10.1080/21691401.2021.1876718
更新日期:2021-12-01 00:00:00
abstract::Acute hepatopancreatic necrosis disease (AHPND) is a major debilitating disease that causes massive shrimp death resulting in substantial economic losses in shrimp aquaculture. The Pir toxin proteins secreted by a unique strain of Vibrio parahaemolyticus play an essential role in the pathogenesis of AHPND. At present,...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1872171
更新日期:2021-12-01 00:00:00
abstract::Metabolic homoeostasis in adipose tissue plays a major role in obesity-related insulin resistance (IR). Regulatory T (Treg) cells have been recorded to regulate metabolic homoeostasis in adipose tissue. However, their specific mechanism is not yet known. This review aims to present the role of Treg cells and other imm...
journal_title:Adipocytepub_type: 杂志文章
doi:10.1080/21623945.2021.1876375
更新日期:2021-12-01 00:00:00
abstract::The binding mode of aromatic sulphonamides and clinically licenced drugs to the three carbonic anhydrase (CA, EC 4.2.1.1) isoforms from the human pathogen V. cholerae was here thouroghly characterised by a joint docking and molecular dynamics in silico protocol. In fact, VchCA, VchCAβ, and VchCAγ are crucial in the pa...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1862102
更新日期:2021-12-01 00:00:00
abstract::Involvement of extracellular nicotinamide phosphoribosyltransferase (eNAMPT, i.e., visfatin or pre-B-cell colony-enhancing factor), a cancer metabokine, in chronically hepatitis C virus (HCV)-infected (CHC) patients with sustained virological responses (SVRs) remains elusive. This 8-year prospective cohort study evalu...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2020.1870080
更新日期:2021-12-01 00:00:00
abstract::Cancer-targeted drug delivery systems based on nanoparticles (NPs) have been considered promising therapies. In this study, we developed a pH-responsive smart NPs drug delivery system using silk fibroin (SF), selenium nanoparticles (Se NPs), fingolimod (FTY720), and heptapeptide (T7). The prepared FTY720@T7-SF-Se NPs ...
journal_title:Artificial cells, nanomedicine, and biotechnologypub_type: 杂志文章
doi:10.1080/21691401.2021.1871620
更新日期:2021-12-01 00:00:00
abstract::The C2-WW-HECT-domain E3 ubiquitin ligase SMURF2 emerges as an important regulator of diverse cellular processes. To date, SMURF2-specific modulators were not developed. Here, we generated and investigated a set of SMURF2-targeting synthetic peptides and peptidomimetics designed to stimulate SMURF2's autoubiquitinatio...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1871337
更新日期:2021-12-01 00:00:00
abstract::Candida albicans is the most prevalent fungal pathogen in humans, particularly in immunocompromised patients. In this study, by screening a C. albicans mutant library, we first identified that the MSS2 gene, an ortholog of Saccharomyces cerevisiae MSS2 required for mitochondrial respiration, mediates chitosan resistan...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2020.1870082
更新日期:2021-12-01 00:00:00
abstract::Recent findings have shown that nanovesicles preparations from either primary immune cells culture supernatants or plasma contain immunoglobulins, suggesting that a natural way of antibody production may be through exosome release. To verify this hypothesis, we used the OKT3 hybridoma clone, which produces a murine Ig...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1852401
更新日期:2021-12-01 00:00:00
abstract::Objectives: To analyze the outcomes of patients who received autologous stem cell transplantation (auto-SCT), matched sibling donor stem cell transplantation (MSD-SCT) and haploidentical stem cell transplantation (haplo-SCT) and provide the basis for the choice of transplantation method in Philadelphia chromosome-posi...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2020.1868783
更新日期:2021-12-01 00:00:00
abstract::Endoplasmic reticulum stress (ERS)-mediated autophagy is indispensable for modulation of replication and pathogenesis of numerous mammalian viruses. We have previously shown that classical swine fever virus (CSFV) infection induces ERS-mediated autophagy for maintaining viral replication both in vivo and in vitro, how...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2020.1845040
更新日期:2021-12-01 00:00:00
abstract::Polymyxin B (PMB) is increasingly used as a last-line antibiotic; however, the emergence of PMB resistance is a serious threat to global health. Here, a total of 40 Acinetobacter baumannii clinical isolates were collected to screen for PMB-resistant strains. Several clinical isolates including NCCP 16007 were far more...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2020.1867421
更新日期:2021-12-01 00:00:00
abstract::Human adipose-derived stem cells (hADSCs) are adult mesenchymal cells that have attracted the interest of clinical scientists and surgeons due to their large number of advantages including ease of access and expansion, abundance in cell culture, high proliferative rates, and lower senescence. SUMO/sentrin specific pro...
journal_title:Adipocytepub_type: 杂志文章
doi:10.1080/21623945.2020.1863625
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVES:Acute lymphoblastic leukemia (ALL) is one of the most common malignancies in children. Our aim was to identify a novel miRNA that can predict prognosis of childhood ALL patients and explore its potential mechanism. METHODS:The miRNA expression profiles of childhood ALL were analyzed using GEO database and H...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2020.1860187
更新日期:2021-12-01 00:00:00
abstract::Enhanced serum secreted clusterin (sCLU) protein was associated with progression, poor prognosis and chemotherapy sensitivity evaluation in malignant patients. However, the clinical significance of serum sCLU protein levels in patients with invasive breast cancer (IBC) is unknown. In this study, the serum sCLU protein...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2020.1868732
更新日期:2021-12-01 00:00:00
abstract::Based on previous studies, 66 2-phenyl-4H-chromone derivatives containing amide and 1,3,4-oxadiazole moieties were prepared as potential telomerase inhibitors. The results showed most of the title compounds exhibited significantly inhibitory activity on telomerase. Among them, some compounds demonstrated the most pote...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1864630
更新日期:2021-12-01 00:00:00
abstract::This study was aimed to identify and optimize the culture conditions for gamma-aminobutyric acid (GABA) production by a lactic acid bacterium strain isolated from mam nem, a fermented fish sauce. Among the six isolates obtained from mam nem, the MN12 had the most potent GABA-producing capability. The strain was then i...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2020.1857626
更新日期:2021-12-01 00:00:00
abstract::In this study, novel carbon dots (CDs) were discovered and separated from Artemisiae Argyi Folium Carbonisata (AAFC) aqueous extract. AAFC-CDs were characterised by a series of methods, mainly including electron microscopy, optical technology and X-ray photoelectron spectroscopy (XPS). Results displayed that AAFC-CDs ...
journal_title:Artificial cells, nanomedicine, and biotechnologypub_type: 杂志文章
doi:10.1080/21691401.2020.1862134
更新日期:2021-12-01 00:00:00
abstract::Coronaviruses (CoVs) are potential pandemic pathogens that can infect a variety of hosts and cause respiratory, enteric, hepatic and neurological diseases. Nonstructural protein 3 (nsp3), an essential component of the replication/transcription complex, is one of the most important antiviral targets. Here, we report th...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2020.1865840
更新日期:2021-12-01 00:00:00
abstract::The serine/threonine protein kinases CDK2 and GSK-3β are key oncotargets in breast cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids were designed and synthesised as dual CDK2/GSK-3β inhibitors targeting breast cancer (5a-g, 7a-h, and 13a-b). The N1 -unsubstituted oxindole ...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1862101
更新日期:2021-12-01 00:00:00
abstract::Melioidosis is an often lethal tropical disease caused by the Gram-negative bacillus, Burkholderia pseudomallei. The study objective was to characterize transcriptomes in melioidosis patients and identify genes associated with outcome. Whole blood RNA-seq was performed in a discovery set of 29 melioidosis patients and...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2020.1858176
更新日期:2021-12-01 00:00:00
abstract::The inhibition of α-glucosidase and DPP enzymes capable of effectively reducing blood glucose level in the management of type 2 diabetes. The purpose of the present study is to evaluate the inhibitory potential of α-glucosidase and DPP (IV) activity including with the 2-NBDG uptake assay and insulin secretion activiti...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1844680
更新日期:2021-12-01 00:00:00
abstract::2- or 4-Substituted 3-N-benzyltriazolylmethyl-13α-oestrone derivatives were synthesised via bromination of ring A and subsequent microwave-assisted, Pd-catalysed C(sp2)-P couplings. The antiproliferative activities of the newly synthesised brominated and phosphonated compounds against a panel of human cancer cell line...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1838500
更新日期:2021-12-01 00:00:00
abstract::Developing efficient strategy for nanomaterials dispersion is the key for promoting the utilization of cellulose-based composite in energy storage devices. In this study, an instant synthesis method for cellulose nanofiber (CNF)/reduced graphene oxide (rGO) composite film with a deep eutectic solvent (DES) based on ch...
journal_title:Carbohydrate polymerspub_type: 杂志文章
doi:10.1016/j.carbpol.2021.118514
更新日期:2021-11-15 00:00:00
abstract::Heparan sulfate (HS) is extensively expressed in cells, for example, cell membrane and extracellular matrix of most mammalian cells and tissues, playing a key role in the growth and development of life by maintaining homeostasis and implicating in the etiology and diseases. Recent studies have revealed that HS is invo...
journal_title:Carbohydrate polymerspub_type: 杂志文章,评审
doi:10.1016/j.carbpol.2021.118490
更新日期:2021-11-15 00:00:00
abstract::The potential isolation of bio-active polysaccharides from bay tree pruning waste was studied using sequential subcritical water extraction using different time-temperature combinations. The extracted polysaccharides were highly enriched in pectins while preserving their high molecular mass (10-100 kDa), presenting id...
journal_title:Carbohydrate polymerspub_type: 杂志文章
doi:10.1016/j.carbpol.2021.118477
更新日期:2021-11-15 00:00:00
abstract::Sustainable industry practices and circular economy concepts encourage the transformation of production waste into by-products. Saccharomyces cerevisiae is widely used in fermentation industry worldwide, generating large amounts of spent yeast which is mainly directed to animal feed or discarded as waste. Instead of b...
journal_title:Carbohydrate polymerspub_type: 杂志文章
doi:10.1016/j.carbpol.2021.118467
更新日期:2021-11-15 00:00:00
abstract::Undiluted l-phenylalanine has been cooled to 6K and its transmission spectrum obtained under terahertz radiation from a synchrotron source. Three distinct absorption bands are evident: at 1.37, 2.14, and 2.32THz. Each of these tracks to lower frequency ("redshifts") as the temperature is increased from 6 to 250K. The ...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119922
更新日期:2021-11-05 00:00:00
abstract::Visualizing and tracking mitochondrial changes is the key to understand the processes of diseases related to mitochondria, which is meaningful to physiology, pathology, and pharmacology. So, a great deal of mitochondrial probes was designed and synthesized according to the principle that probes with a positive charge ...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119979
更新日期:2021-11-05 00:00:00
abstract::In this work, blue emission fluorescent carbon dots (CDs) were fabricated by using the hydrothermal strategy from coix seed for the first time. We found that the prepared CDs possessed many excellent characteristics including excitation-dependent properties, good solubility and strong photostability. The optimal excit...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119969
更新日期:2021-11-05 00:00:00
abstract::The World Health Organization (WHO) grade diagnosis of cancer is essential for surgical outcomes and patient treatment. Traditional pathological grading diagnosis depends on dyes or other histological approaches, and the result interpretation highly relies on the pathologists, making the process time-consuming (>60 mi...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119946
更新日期:2021-11-05 00:00:00
abstract::A novel silylated azo compound was synthesized and fully characterized. This compound was used in a chromogenic chemodosimeter approach for the highly selective detection of cyanide (CN-) in acetonitrile/water and in an aqueous micellar system. The anion breaks the Si-O bond, delivering a dye and causing a change in t...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119950
更新日期:2021-11-05 00:00:00
abstract::A novel ratiometric fluorescent probe has been developed through a simple synthetic route for the detection of alkaline phosphatase(ALP) in aqueous media and for fluorescence imaging in living cells. The introduction of a spontaneous-degradation spacer in the design of the fluorescent probe is beneficial for the ratio...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119953
更新日期:2021-11-05 00:00:00
abstract::EG (ethylene glycol) is a good model system for the study of the fundamental hydrogen bonds in aqueous solutions. Using Raman spectroscopy, we have investigated the EG volume fraction induced variation in the hydrogen bonding interactions and conformations of EG-H2O (water) binary solutions. New hydrogen bonding netwo...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119916
更新日期:2021-11-05 00:00:00
abstract::The present work reports a highly efficient Ca doped Eu: Y2O3 i.e Ca0.05Eu0.01Y1.94O3 (CEY.) nanophosphor material synthesized through a facile combustion method, as a simple and selective turn-off fluorescence probe for the quantitative analysis of iron ions (Fe3+). The proposed sensor allows the quantification of ir...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119942
更新日期:2021-11-05 00:00:00
abstract::Fluorescence spectroscopy, including Stern-Volmer quenching, is a valuable tool for the study of protein dynamics. Changes in protein solvation during the folding reaction of a membrane protein, Outer membrane protein A (OmpA), into lipid bilayers was probed with bimolecular fluorescence quenching with acrylamide quen...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119919
更新日期:2021-11-05 00:00:00
abstract::Due to the relevance to excited-state processes, sensing mechanisms of fluorescent probes were difficult to study directly by experimental methods. This work investigated theoretically the sensing mechanism of a reported bifunctional fluorescent probe to detect intracellular hydroxyl radicals and their environmental v...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119928
更新日期:2021-11-05 00:00:00
abstract::This article presents the potential health benefits of Rooibos to be considered a support during the COVID-19 pandemic. The recent pandemic of COVID-19 has led to severe morbidity and mortality. The highly infectious SARS-CoV-2 is known to prime a cytokine storm in patients and progression to acute lung injury/acute r...
journal_title:Journal of functional foodspub_type: 杂志文章,评审
doi:10.1016/j.jff.2021.104684
更新日期:2021-11-01 00:00:00
abstract::Given the important role of green environments playing in healthy cities, the inequality in urban greenspace exposure has aroused growing attentions. However, few comparative studies are available to quantify this phenomenon for cities with different population sizes across a country, especially for those in the devel...
journal_title:Environment internationalpub_type: 杂志文章
doi:10.1016/j.envint.2021.106778
更新日期:2021-11-01 00:00:00